2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-D0004
    Azure B 531-55-5 98.13%
    Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects.
    Azure B
  • HY-D0953
    Direct Blue 86 1330-38-7 99.50%
    Direct Blue 86 (Solvent Blue 38) is a myelin-sheath stain, commonly utilized in microscopy to detect demyelination in the central nervous system. Direct Blue 86 also is a dye with various applications including as a commercial dye in the printing of cotton and mucilage glue fabrics.
    Direct Blue 86
  • HY-D1387
    Naloxone fluorescein acetate 2080300-52-1 98%
    Naloxone fluorescein acetate is the fluorescent-derivative of Naloxone. Naloxone is an opioid antagonist. Naloxone is the antidote for reversing the effects of an opioid overdose.
    Naloxone fluorescein acetate
  • HY-D1427
    Di-2-ANEPEQ 160605-94-7
    Di-2-ANEPEQ is a voltage sensitive membrane potential fluorescence dye. Di-2-ANEPEQ can be used for the evaluation of voltage-sensitive fluorescence dyes for monitoring neuronal activity in the embryonic central nervous system.
    Di-2-ANEPEQ
  • HY-D1515
    FM1-84 303727-66-4 98.92%
    FM1-84 (Neurodye GH1-84) is a fluorescent dye. FM1-84 has lipophilic and facilitates association with membranes, resulting in an increase in fluorescence intensity (λex=510 nm, λem=625 nm). FM1-84 can be used for synaptic vesicle recycling in neurons research.
    FM1-84
  • HY-D1631
    Calcium Green-5N AM 216699-33-1
    Calcium Green-5N AM is a novel Ca2+-sensitive fluorescent probe. Calcium Green-5N AM shows enhancement in fluorescence intensity on binding Ca2+, and can monitor free Ca2+ in neurons.
    Calcium Green-5N AM
  • HY-N0050
    Allomatrine 641-39-4 99.36%
    Allomatrine ((+)-Allomatrine) is an alkaloid from the bark of Sophora japonica. Allomatrine has antinociceptive properties mediated mainly through the activation ofκ-opioid receptors.
    Allomatrine
  • HY-N0226
    Epiberberine 6873-09-2 98.46%
    Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and can be used for the research of Alzheimer disease. Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways. Epiberberinecan be used for the research of diabetic disease.
    Epiberberine
  • HY-N0343
    Helicid 80154-34-3 98.13%
    Helicid (Helicide) is a major constituent of Helicia nilgirica Bedd. Helicid has been used to treat psychoneurosis for its analgesic properties.
    Helicid
  • HY-N0582
    Otophylloside B 106758-54-7 ≥99.0%
    Otophylloside B, a C-21 steroidal glycoside isolated from Qingyangshen. Otophylloside B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Otophylloside B has antiepileptic activity.
    Otophylloside B
  • HY-N0749
    Jatrorrhizine 3621-38-3 98%
    Jatrorrhizine is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE. Jatrorrhizine reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters.
    Jatrorrhizine
  • HY-N0833
    L-Hisidine (monohydrocholoride) 645-35-2
    L-Hisidine is an essential amino acid for infants. L-Hisidine is an inhibitor of mitochondrial glutamine transport.
    L-Hisidine (monohydrocholoride)
  • HY-N1187
    Syzalterin 94451-48-6 99.05%
    Syzalterin is an inhibitor of NO production with an IC50 of 1.87 μg/mL.
    Syzalterin
  • HY-N1745
    2'-O-Methylisoliquiritigenin 51828-10-5 98.44%
    2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA and GABA pathways, but does not put a very significant effect on ne NE pathway.
    2'-O-Methylisoliquiritigenin
  • HY-N2272
    Cnidilin 14348-22-2 ≥99.0%
    Cnidilin (Knidilin) is isolated from the root of Angelica dahurica.
    Cnidilin
  • HY-N2326
    (±)-Anatoxin A fumarate 1219922-30-1 ≥98.0%
    (±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to putative α4β2-type nAChR and α7-type nAChR in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM).
    (±)-Anatoxin A fumarate
  • HY-N2401
    Baldrinal 18234-46-3 99.60%
    Baldrinal is derived from the extracts of valerian rhizomes and roots, inhibits autonomic activity, and has anti-inflammatory effects.
    Baldrinal
  • HY-N2604
    Loureirin C 116384-24-8 99.69%
    Loureirin C has anti-bacterial, anti-spasmodic, anti-inflammatory, analgesic, anti-diabetic, and anti-tumor activities.
    Loureirin C
  • HY-N2707
    6-Deoxyjacareubin 16265-56-8 ≥98.0%
    6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS).
    6-Deoxyjacareubin
  • HY-N2740
    Agalloside 221257-06-3 ≥98.0%
    Agalloside is a neural stem cell differentiation activator that can be found in Aquilaria agallocha.
    Agalloside
Cat. No. Product Name / Synonyms Application Reactivity